First of all, if you think your breasts are too big to be incompatible with your body,

If your breasts are aesthetically unpleasent because of their size,

If you think your lifestyle and exercise capacity are limited due this reason,

Back, shoulder, waist or neck pain related to breast size,

Mushroom and rash under your breast fold

If your breasts arer asymmetrical , you can be a candidate for reduction surgery.